A new aspect on the correlation of ten SNPs in MIR and their target genes in dopaminergic pathways in schizophrenia
نویسندگان
چکیده
Abstract Background Schizophrenia (SCZ) is a severe mental disorder in which people interpret reality abnormally. Different studies indicated complex polygenic control over SCZ. In the present study, we investigated potential correlation between ten SNPs among MicroRNA (MIR) and their target genes; rs369770942, rs143525573, rs200982455, rs530404895, rs753764536, rs374732351, rs4680, rs165599, rs340597269, rs10759, schizophrenia Iranian population. Results The results revealed that T allele rs200982455 increased risk factor by 3.19 times. We obtained significant association rs165599 codominant, dominant, overdominant inheritance models ( P = 0.016, 0.01, 0.004, respectively). Moreover, of presence G up to 2.12, 2.35, 2.28 times, respectively. A rs10759 1.05 Conclusion Our finding showed some studied within genes MIRs involved dopaminergic pathway may consider as biomarker diagnostic patterns Schizophrenia.
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ژورنال
عنوان ژورنال: Bulletin of the National Research Centre
سال: 2022
ISSN: ['2522-8307', '1110-0591']
DOI: https://doi.org/10.1186/s42269-022-00744-w